Transplant & Hepatobiliary Surgical Specialists at Largo provides state–of–the–art, life–saving surgical treatment for patients suffering from kidney disease, liver disease and pancreatic cancer. Our highly skilled and experienced physicians specialize in performing kidney and liver transplants and hepatobiliary pancreatic surgery.

Below are some of the procedures performed at Transplant Surgical Specialists at Largo.

Hepatobiliary Pancreatic Surgery

This complex surgical procedure treats benign and malignant diseases of the liver, pancreas, gallbladder, and bile ducts.

Hepatobiliary disease is disease that affects the liver, bile ducts, and gallbladder and can be caused by viral, bacterial, and parasitic infections, neoplasia, toxic chemicals, alcohol consumption, poor nutrition, metabolic disorders, and cardiac failure. The two predominant diseases of the liver in the United States are viral hepatitis and cirrhosis; the predominant chronic disease of the biliary system is cholelithiasis.

Hepatitis C is the #1 cause of Liver Cancer and Liver Transplant in the United States. 3.5 Million people are infected with hepatitis C in United States.

According the Center for Disease Control (CDC) Baby Boomers (people born from 1945–1965) are 5 times more likely to have hepatitis C than other adults

Learn more about Hepatitis C (pdf)

Kidney Transplants

A kidney transplant becomes necessary when kidney function declines and a patient develops end-stage renal disease. End-stage renal disease occurs as a result of renal failure, or when the kidneys stop working to effectively filter waste from blood, regulate blood pressure and stimulate the production of red blood cells. This results in a build-up of toxic waste in the body.

Patients can receive a kidney transplant from either a living or deceased donor. A donor match is carefully tested and screened through tests on blood type and tissue type. A crossmatch test is also performed to ensure the donor kidney does not carry any antibodies the recipient would negatively react to after the transplant surgery is completed.

During the transplant surgery, which typically takes between 2-4 hours, the original kidneys are not removed from the body, and the donor kidney is surgically placed in the front area of the pelvis. Patients can expect a 3-7 day hospital recovery period.

Liver Transplantation

The liver is one of the body's largest organs and has a large range of important biological functions. It supports nearly every organ in the body and plays a key role in regulating metabolism, detoxifying the body of harmful substances, and digestion. The liver has sizable reserves and a great capacity to regenerate itself. Often, symptoms aren't evident until significant damage has been done. At present, there is no known way to medically compensate for the loss of a liver.

Liver transplantation replaces a severely diseased or irreversibly damaged liver with a healthy one. Most often, the new liver will come from a deceased donor.

Liver transplants are reserved for the critically ill because the demand for available livers far outweighs the supply. Patients may spend many months waiting for a liver. Nationally, about 6,000 liver transplants are performed each year.

Biology & Causes

Liver transplantation is reserved for patients with end-stage irreversible liver failure, and for whom other treatments have proven ineffective. Occasionally, transplantation is also an option for some patients with liver cancer.

When a liver is damaged slowly over time, the condition is known as chronic liver disease. When it occurs rapidly, often in a matter of weeks, it's known as acute liver failure.

The causes of liver failure are many, and include among others:

  • End stages of cirrhosis - Liver cells are replaced by scar tissue, causing a loss of liver function. Often caused by alcoholism and hepatitis B and C.
  • Fulminant hepatic failure - Acute liver failure without any history of liver disease.
  • Selected patients with Primary liver cancer (hepatocellular carcinoma) - Interferes with normal liver function.
  • End stages of Hemochromatosis - Excess iron accumulation in the body.
  • Alpha-1 antitrypsin deficiency affecting the liver - Incorrect production of A1AT.
  • Metabolic disorders - Any metabolic disorder that leads to liver disease and additional complications.


If you would like to learn more about the transplant process at Largo Medical Center, feel free to check out one of these educational webinars from the comforts of your own home.